• Research Paper on:
    APOE and the Risk of Developing Late Onset Alzheimer's Disease

    Number of Pages: 5

     

    Summary of the research paper:

    For over a decade, researchers have considered the issue of the presence of genetic factors as predictors of late-onset AD. This study proposal is designed to consider the perspectives presented in the current literature and the viewpoints of researchers on a variety of levels, to consider whether APOE is a substantial predictor. This 5 page paper provides an overview of the issue presented and relates it to the current literature. Bibliography lists 5 sources.

    Name of Research Paper File: MH11_MHDemen2.rtf

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    perspectives presented in the current literature and the viewpoints of researchers on a variety of levels, to consider whether APOE is a substantial predictor. Further, this research proposal focuses  on the importance of APOE even in the midst of research that suggests that other genetic factors may also play a role in predicting onset, including the age of  onset. This proposal focuses on the assessment of APOE and the comparative view of the current literature as a basis for understanding arguments that other genetic factors have substantial  importance as predictors of onset of AD. INTRODUCTION Since the early 1990s, a number of studies have assessed possible causative factors of Alzheimers disease (AD), and possible risk  factors for the development of late onset AD. Initially, researchers considered environmental factors, cognitive issues and mental health factors, all of which have been deemed contributing factors in the  development of this disease (APA, 1994). Over the course of the last ten years, though, researchers have attempted to determine the impact of certain genetic factors as a predictor  of late onset AD, including the presence of the apoliprotein E (APOE). Many studies have been conducted about the importance of APOE as a predictor for late onset AD,  but questions still remain regarding the accuracy of the argument that the presence of APOE is a substantial predictor for late-onset AD. Statement of the  Problem In recent years, a number of researchers have supported the correlation between the presence of the APOE gene and the development of late onset Alzheimers disease (AD) (Daw et  al, 2000). In fact, there is general agreement about the correlation between the presence of APOE and the development of late onset AD, but the extent to which this 

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