• Research Paper on:
    Methadone Toxicity An

    Number of Pages: 8

     

    Summary of the research paper:

    8 page research paper that discusses methadone toxicity. Bibliography lists 9 sources.

    Name of Research Paper File: D0_khmettox.rtf

    Buy This Research Paper »

     

    Unformatted Sample Text from the Research Paper:
    These negative outcomes were reported particularly in connection with patients who were recently placed on methadone for pain control. The FDA also indicate that prescribing methadone is a complex issue,  as while methadones analgesic effects last about 4 to 8 hours, it tends to be retained by the body and can reach toxic levels if taken too frequently (Methadone, 2007).  The following literature will examine issues pertaining to methadone use and its potential for toxicity. Background In 1939, Otto Eisleb and his colleagues, scientists at a large German  chemical conglomerate, discovered an analgesic drug that they labeled "compound 8909" or "Dolantin" (History, 2008). Further development occurred in wartime Germany and a patent was filed on September 11, 1941  by Bockmuhl and Ehrhart for drug that they referred to as "polamidon" (History, 2008). After World War II, the German chemical conglomerate where these drugs were developed, I.G. Farbenindustrie, came  under American management. The formulas discovered by the German scientists were published, which sparked pharmaceutical companies, such as Eli-Lilly, to begin clinical trials and commercial production. From the beginning of  methadones history, its addictive qualities were noted, as well as its analgesic and euphoria producing effects (History, 2008). As of 2001, it was estimated that between 500,000 and 1  million Americans were believed to be addicted to opioids at some point in their lives (Krambeer, et al, 2001). While this demographic group includes both men and women, opioid-related disorders  are much more prevalent among men by a factor of up to 4 to 1 (Krambeer, et al, 2001). Opioid addiction is frequently related to a history of drug-related  criminal behavior. Antisocial personality disorder, as well as other comorbid mood disorders, particularly depression, occur at a higher incidence among opioid dependent patients than among the general population (Krambeer, 

    Back to Research Paper Results