Research Paper on:
Article Critique of Prader Willi Syndrome and Food Preferences

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the amount of energy taken in and the amount of energy expended. However, Fieldstone, et al (1997) explain that the precise cause of obesity are unclear. Thus far, research suggests  that "obesity is multifactorial, polygenic and environmentally influenced" (Fieldstone, et al, 1997, p. 1046). Variable factors between individuals can include differences in metabolism and rate of lipogenesis, but it may  also be true that not all calories contribute equally to weight gain. For example, the authors speculate that the overall maconutrient content of a diet may be a factor  that leads to increased caloric intake. Furthermore, research suggests that there is some connection between differentiated central mechanisms and neuro-transmitter systems that involves the regulation of specific macronutrient intakes.  These findings cause the research team posit that greater attention should be paid to food preferences , i.e. the proportion of carbohydrate, protein and fat within a diet, as well  as patterns of ingestion in obese populations. To this end, Fieldstone, et al (1997) argue that the hyperphagia-associated obesity of Prader-Willi syndrome (PWS) present a possibly significant model of  obesity due to the emerging recognition that this condition is the result of a localized, single genetic abnormality (Fieldstone, et al, 1997). Roughly 70 percent of PWS patients have  a chromosome deletion. The major symptoms of PWS are: infantile hypotonia, failure to thrive, hypogonadism; developmental delay; mental deficiency; childhood-onset hyperphgia and morbid obesity; characteristic facial features and  chromosome 15 deletion. Minor symptoms of PWS are also listed by the research team. Early diagnosis is vital to the control of obesity with PWS patients; however, even when detected  early, weight loss requires an extreme diet of only 500 to 800 calories per day (Fieldstone, et al, 1997). Such a restricted diet is typically lacking in the daily-recommended nutritional